Preclinical Research Tool Innovation in Resource-scarce Setting – A Case Study of a Mouse Anxiety Multi-test Appararus

One of the factors responsible for high prevalence and attendant socio-economic burden anxiety disorders is paucity slow pace discovery new anxiolytic drugs to complement or replace existing ones due attrition rates poor translation preclinical drug efforts clinical usage. This scenario viewed arise from certain including inherent sensitivity idiosyncrasies most used individual classical tests/models when as single assays. thrust this study invent a mouse multi-test that will be devoid limitation. Previous attempts overcome limitation by testing retesting experimental mice on multiple paradigms different times were soon encumbered one-trial tolerance phenomenon subsequent trials. Although apparatus invented Ramos comprising light-dark, plus-, open-field mazes largely limitations observed with apparatuses, central area elevated plus maze in middle triple test still retains some ambiguity errors behavioural thus generated. A novel device light-dark maze, zero-maze, marble-burying mazes, dubbed U. A. Mouse Anxiety Multi-test, would multi- tests one hand, potentially exhibit greater richer anxiety-related behaviours mouse, was conceptualised. The fabrication composite tool made locally sourced materials using simple tools requiring minimal space. so generated cost-effective – costing about 4 percent worth its foreign counterparts. It environmentally safe, portable, operationally simple. Initial assessment indicate it can generate state mice. innovation potential asset research discovery. However, there need further pharmacological evaluation automation.